Genetic deletion of PKR abrogates TNF-induced activation of IκBα kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

Osman Nidai Özeş, Lindsey D. Mayo, Jason A. Gustin et al. · Nature · 1999 · 2.2K citations

Inflammation, Cytokine, Tumour Necrosis Factor +15

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

Hailing Hsu, Hong-Bing Shu, Ming-Gui Pan et al. · Cell · 1996 · 2K citations · Full text

Signal Transduction Pathways, Molecular Physiology, Signal Transduction +8

NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1

Denis C. Guttridge, Chris Albanese, Julie Y. Reuther et al. · Molecular and Cellular Biology · 1999 · 1.3K citations · Full text

Cyclin D1, Immunology, Immune Regulation +18

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappa B that blocks TNFalpha -induced apoptosis

W.-X. Zong, Leonard C. Edelstein, Chi Chen et al. · Genes & Development · 1999 · 725 citations · Full text

Apoptosis, Immunology, Cell Death +17

Nuclear Factor (NF)-κB–regulated X-chromosome–linked <i>iap</i> Gene Expression Protects Endothelial Cells from Tumor Necrosis Factor α–induced Apoptosis

Christian Stehlik, Rainer de Martin, Ichiro Kumabashiri et al. · The Journal of Experimental Medicine · 1998 · 633 citations · Full text