QSAR studies—potent benzodiazepine γ-secretase inhibitors

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

Martin Citron, Tilman Oltersdorf, Christian Haass et al. · Nature · 1992 · 1.7K citations

Life Sciences, Molecular Biology, Neurology +16

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

Eric H. Schroeter, Jeffrey A. Kisslinger, Raphael Kopan · Nature · 1998 · 1.6K citations

Life Sciences, Cell Biology, Molecular Biology +13

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

Nobuhiro Suzuki, Tobun T. Cheung, Xiao-Dan Cai et al. · Science · 1994 · 1.5K citations

Life Sciences, Biochemistry, Molecular Biology +16

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

Xiao-Dan Cai, Todd E. Golde, Steven G. Younkin · Science · 1993 · 911 citations

Life Sciences, Molecular Biology, Neuroscience +17

Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm

Philip C. Wong, Hui Zheng, Hua Chen et al. · Nature · 1997 · 718 citations

Life Sciences, Cell Biology, Genetics +12