DIFFERENTIAL INHIBITION OF PROSTACYCLIN PRODUCTION AND PLATELET AGGREGATION BY ASPIRIN

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

Medicine, Biochemistry, Pharmacology +16

Acetylation of prostaglandin synthase by aspirin.

G J Roth, N Stanford, Philip W. Majerus · Proceedings of the National Academy of Sciences · 1975 · 1K citations · Full text

Life Sciences, Biochemistry, Pharmacology +14

Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides

Ryszard J. Gryglewski, Stuart Bunting, Salvador Moncada et al. · Prostaglandins · 1976 · 1K citations

Medicine, Cardiology, Hematology +13

HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATION

Salvador Moncada, E.A. Higgs, John R. Vane · The Lancet · 1977 · 887 citations

Medicine, Hematology, Pharmacology +13

The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein.

G J Roth, Philip W. Majerus · Journal of Clinical Investigation · 1975 · 862 citations · Full text

Medicine, Biochemistry, Pharmacology +15