Reduced DNA topoisomerase II in VP-16 resistant mouse breast cancer cell line

Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide.

Eric M. Nelson, K M Tewey, Leroy F. Liu · Proceedings of the National Academy of Sciences · 1984 · 562 citations

Medicine, Molecular Biology, Pharmacology +15

Cleavage of DNA by mammalian DNA topoisomerase II.

Leroy F. Liu, Thomas C. Rowe, K M Tewey et al. · Journal of Biological Chemistry · 1983 · 533 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.

G L Chen, Thomas C. Rowe, Brian Halligan et al. · Journal of Biological Chemistry · 1984 · 499 citations · Full text

Medicine, Molecular Biology, Oncology +11

Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22.

M Tsai-Pflugfelder, Leroy F. Liu, A A Liu et al. · Proceedings of the National Academy of Sciences · 1988 · 397 citations · Full text

Life Sciences, Genetics, Molecular Biology +10

Direct correlation between DNA topoisomerase II activity and cytotoxicity in adriamycin-sensitive and -resistant P388 leukemia cell lines.

Abdul M. Deffie, Janendra K. Batra, Gerald J. Goldenberg · PubMed · 1989 · 263 citations

Medicine, Molecular Biology, Oncology +14