Publication | Open Access
Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.
499
Citations
20
References
1984
Year
Molecular BiologyTumor BiologySpecific EffectNonintercalative Antitumor DrugsAnti-cancer AgentCancer ResearchGenome InstabilityBiochemistryMedicineOligonucleotideDna ReplicationNuclear OrganizationCancer TreatmentPharmacologyChromatinChromatin RemodelingNatural SciencesCleavable ComplexOncologyBreakage-reunion Reaction
shown to cleave DNA indirectly through their specific effect on the stabilization of a cleavable complex formed between mammalian DNA topoisomerase I1 and DNA (Nelson, E.
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