DRUG-INDUCED INHIBITION OF PLATELET FUNCTION DELAYS PROGRESSION OF PERIPHERAL OCCLUSIVE ARTERIAL DISEASE

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

Thrombopoiesis, Thrombosis, Biochemistry +12

"AICLA" controlled trial of aspirin and dipyridamole in the secondary prevention of athero-thrombotic cerebral ischemia.

Marie‐Germaine Bousser, E Eschwège, M Haguenau et al. · Stroke · 1983 · 611 citations · Full text

Cerebrovascular Disease, Pharmacotherapy, Double Blind +22

A Platelet-Inhibitor-Drug Trial in Coronary-Artery Bypass Operations

James H. Chesebro, Ian P. Clements, Valentı́n Fuster et al. · New England Journal of Medicine · 1982 · 543 citations

Effect of Dipyridamole and Aspirin on Late Vein-Graft Patency after Coronary Bypass Operations

James H. Chesebro, Valentı́n Fuster, Lila R. Elveback et al. · New England Journal of Medicine · 1984 · 523 citations

A Randomized Controlled Trial of Acetyl Salicyclic Acid in the Secondary Prevention of Mortality from Myocardial Infarction

P C Elwood, Alexandra Cochrane, M L Burr et al. · BMJ · 1974 · 518 citations · Full text

Hypertension, Heart Failure, Total Mortality +17