Synthesis and antimicrobial evaluation of 1,4-disubstituted 1,2,3-triazoles with aromatic ester functionality

Abstract

A series of 1,4-disubstituted 1,2,3-triazoles having p-substituted aromatic ester functionality were synthesized via Cu(I) catalysed click reaction between p-substituted benzoic acid prop-2-ynyl esters and aralkyl azides. The synthesized triazoles were characterized by IR, 1H NMR, 13C NMR and mass spectral techniques. These compounds were evaluated for their antimicrobial activity against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Mycobacterium tuberculosis, Candida albicans, Aspergillus niger and Aspergillus flavus by two fold serial dilution method. Some of the synthesized 1,4-disubstituted 1,2,3-triazoles possess comparable or even better antibacterial, antitubercular and antifungal activities than reference drugs against tested bacterial, mycobacterial and fungal strains, respectively.