Concepedia

Inhibitors of HIV‐1 Protease by Using In Situ Click Chemistry

Matthew Whiting, John Muldoon, Ying‐Chuan Lin, Steven M. Silverman, William Lindstrom, Arthur J. Olson, Hartmuth C. Kolb, M. G. Finn, K. Barry Sharpless, John H. Elder,

Angewandte Chemie International Edition · 2006 · 510 citations · 22 references

DOI

Concepts

Abstract

Twice poor equals potent: HIV-1 Protease assembles its own potent inhibitor through formation of the triazole linkage from azide- and alkyne-containing fragments that are themselves poor binders.

References

22

A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes

Vsevolod V. Rostovtsev, Luke G. Green, Valery V. Fokin et al. · Angewandte Chemie International Edition · 2002 · 11.5K citations

, , +8

Peptidotriazoles on Solid Phase:  [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides

Christian W. Tornøe, Caspar Christensen, Morten Meldal · The Journal of Organic Chemistry · 2002 · 8.5K citations

, , +12

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

Akio Adachi, Howard E. Gendelman, Scott Koenig et al. · Journal of Virology · 1986 · 2.9K citations · Full text

, , +16

Active human immunodeficiency virus protease is required for viral infectivity.

Nancy E. Kohl, Emilio A. Emini, William A. Schleif et al. · Proceedings of the National Academy of Sciences · 1988 · 1.3K citations · Full text

, , +17

In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors

Jon H. Condra, William A. Schleif, O M Blahy et al. · Nature · 1995 · 979 citations

, , +16