CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection

Microbial translocation is a cause of systemic immune activation in chronic HIV infection

Jason M. Brenchley, David A. Price, Timothy W. Schacker et al. · Nature Medicine · 2006 · 3.5K citations

Life Sciences, Immunology, Infectious Diseases +17

Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection

Joseph J. Mattapallil, Daniel C. Douek, Brenna J. Hill et al. · Nature · 2005 · 1.3K citations

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Shorter Survival in Advanced Human Immunodeficiency Virus Type 1 Infection Is More Closely Associated with T Lymphocyte Activation than with Plasma Virus Burden or Virus Chemokine Coreceptor Usage

Janis V. Giorgi, Lance E. Hultin, Jane A. McKeating et al. · The Journal of Infectious Diseases · 1999 · 1K citations

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HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression

Christine J. Pitcher, Claudia Quittner, Dolores M. Peterson et al. · Nature Medicine · 1999 · 748 citations

Life Sciences, Immunology, Infectious Diseases +14

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

Amin Rahemtulla, Wai‐Ping Fung‐Leung, Marco W. Schilham et al. · Nature · 1991 · 685 citations

Life Sciences, Developmental Biology, Immunology +17