Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit

Marija S. Nadjsombati, John W. McGinty, Miranda R. Lyons‐Cohen, +12

Immunity

InflammationAutoimmune DiseaseMucosal ImmunologyInnate Immune SystemImmunology +10

Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity

John W. McGinty, Hung-An Ting, Tyler E. Billipp, +6

Immunity

InflammationMucosal ImmunologySmall IntestineAre DispensableImmunology +7

The cysteinyl leukotriene 3 receptor regulates expansion of IL-25–producing airway brush cells leading to type 2 inflammation

Lora G. Bankova, Daniel F. Dwyer, Eri Yoshimoto, +7

Science Immunology

InflammationCytokineInflammatory Lung DiseaseAllergyLung Inflammation +12

Recognition of Posttranslationally Modified GAD65 Epitopes in Subjects With Type 1 Diabetes

John W. McGinty, I‐Ting Chow, Carla J. Greenbaum, +3

Diabetes

ImmunologyPathologyAntigen ProcessingImmunotherapyInsulin Signaling +18

Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection

N R Klatt, L. D. Harris, Carol L. Vinton, +11

Mucosal Immunology

Pigtail MacaquesDysbiosisMucosal ImmunologyIl-17 ProductionMedicine +6

CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection

Coreen M. Beaumier, Levelle D. Harris, Simoy Goldstein, +7

Nature Medicine

Sivagm InfectionPathogenesisImmunologyImmunodominanceCd4 T Cell Responses +5

Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes

Meghan L. Marré, John W. McGinty, I‐Ting Chow, +10

Diabetes

PGD2 and CRTH2 counteract Type 2 cytokine–elicited intestinal epithelial responses during helminth infection

Oyebola O. Oyesola, Michael T. Shanahan, Matt Kanke, +23

The Journal of Experimental Medicine

Chronic cat allergen exposure induces a TH2 cell–dependent IgG4 response related to low sensitization

Amédée Renand, Luis Diego Archila, John W. McGinty, +5

Journal of Allergy and Clinical Immunology

Tuft cell-derived acetylcholine promotes epithelial chloride secretion and intestinal helminth clearance

Tyler E. Billipp, Connie Fung, Lily M. Webeck, +15

Immunity

InflammationProtein SecretionSignal TransductionIntestinal Helminth ClearanceCell Trafficking +10