Stretch–Activation of Angiotensin II Type 1_aReceptors Contributes to the Myogenic Response of Mouse Mesenteric and Renal Arteries

Abstract

Our results provide definitive evidence that myogenic responses of mouse mesenteric and renal arteries rely on ligand-independent, mechanoactivation of AT1R subtype a. The AT1R subtype a signal relies on an ion channel distinct from TRPC6 or KCNQ3, 4, or 5 to enact vascular smooth muscle cell activation and elevated vascular resistance.