Concepedia

The Fragile X Syndrome Protein FMRP Associates with BC1 RNA and Regulates the Translation of Specific mRNAs at Synapses

Francesca Zalfa, Marcello Giorgi, Beatrice Primerano, Annamaria Moro, Alessandra di Penta, Surya A. Reis, Ben A. Oostra, Claudia Bagni

Cell · 2003 · 679 citations · 53 references

Open access

Concepts

Life SciencesGeneticsMolecular BiologyGene ExpressionMolecular NeuroscienceProtein TranslationProtein SynthesisTranslation ControlTranslation RegulationTranslational ControlTranslational RegulationUntranslated RegionsSynaptic Local TranslationTranslational Regulation In Neuronal FunctionX-linked Intellectual DisabilityX-linked Neurodevelopmental Disorders

References

53

Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

Annemieke J.M.H. Verkerk, Maura Pieretti, James S. Sutcliffe et al. · Cell · 1991 · 3.5K citations

Life Sciences, Genetics, Molecular Genetics +12

Instability of a 550-Base Pair DNA Segment and Abnormal Methylation in Fragile X Syndrome

I. Oberlé, F. Rousseau, Dominique Heitz et al. · Science · 1991 · 1.5K citations

Life Sciences, Genetics, Molecular Genetics +16

Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites

Gregory L. Lyford, Kanato Yamagata, Walter E. Kaufmann et al. · Neuron · 1995 · 1.2K citations · Full text

Medicine, Neurobiology, Neuroscience +17

Microarray Identification of FMRP-Associated Brain mRNAs and Altered mRNA Translational Profiles in Fragile X Syndrome

Victoria Brown, Peng Jin, Stephanie Ceman et al. · Cell · 2001 · 1.1K citations

Life Sciences, Genetics, Molecular Biology +15

Fmr1 knockout mice: A model to study fragile X mental retardation

Cell · 1994 · 1K citations

Life Sciences, Genetics, Molecular Genetics +12