The Inflammasome

Fabio Martinon, Kimberly Burns, Jürg Tschopp

Molecular Cell

Cryopyrin activates the inflammasome in response to toxins and ATP

Sanjeev Mariathasan, David S. Weiss, Kim Newton, +7

Nature

Cell PhysiologyReductive StressSignal TransductionBiochemistryNatural Sciences +9

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

Catherine Dostert, Virginie Pétrilli, Robin van Bruggen, +3

Science

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

Rongbin Zhou, Aubry Tardivel, Bernard Thorens, +2

Nature Immunology

InflammationImmunologyCell DeathInflammasomeRedox Biology +5

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

Veit Hornung, Andrea Ablasser, Marie Charrel-Dennis, +5

Nature

Signal TransductionNatural SciencesCell InteractionImmunologyCell Death +10

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

Sanjeev Mariathasan, Kim Newton, Denise M. Monack, +6

Nature

InflammationAnti-inflammatorySignal TransductionImmunologyChronic Inflammation +9

Activation of Toll-Like Receptor 2 in Acne Triggers Inflammatory Cytokine Responses

Jenny Kim, María Teresa Ochoa, Stephan R. Krutzik, +10

The Journal of Immunology

Inflammatory Lung DiseaseInnate Immune SystemImmunologyInnate ImmunityDermatology +17

<i>NALP1</i> in Vitiligo-Associated Multiple Autoimmune Disease

Ying Jin, Christina M. Mailloux, Katherine Gowan, +5

New England Journal of Medicine

Crystal structure of the cysteine protease interleukin-1β-converting enzyme: A (p20/p10)2 homodimer

Nigel P.C. Walker, Robert V. Talanian, Kenneth D. Brady, +23

Cell

Crystal StructureBiochemistryNatural SciencesProtein X-ray CrystallographyMolecular Biology +2

Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway

Nitza G. Shoham, Michael Centola, Elizabeth Mansfield, +4

Proceedings of the National Academy of Sciences

GeneticsImmunologyPathologyMolecular BiologyCell Death +25