Synthesis and biological activity of novel α-substituted β-phenylpropionic acids having pyridin-2-ylphenyl moiety as antihyperglycemic agents

Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40

Yasuaki Itoh, Yuji Kawamata, Masataka Harada et al. · Nature · 2003 · 1.5K citations

Metabolic Syndrome, Insulin Signaling, Molecular Physiology +14

The Structure−Activity Relationship between Peroxisome Proliferator-Activated Receptor γ Agonism and the Antihyperglycemic Activity of Thiazolidinediones

Timothy M. Willson, Jeffery E. Cobb, David J. Cowan et al. · Journal of Medicinal Chemistry · 1996 · 637 citations · Full text

Altmetric Attention Score, Research Triangle Park, Chemical Biology +18

A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs

Knut Kotarsky, Niclas Nilsson, Erik Flodgren et al. · Biochemical and Biophysical Research Communications · 2003 · 349 citations

Thiazolidinedione Drugs, Lipid Synthesis, Biochemistry +8

Studies on Antidiabetic Agents. X. Synthesis and Biological Activities of Pioglitazone and Related Compounds.

Yū Momose, Kanji Meguro, Hitoshi Ikeda et al. · Chemical and Pharmaceutical Bulletin · 1991 · 284 citations · Full text

Pharmaceutical Science, Biological Activities, Pharmacotherapy +18

Reduction of Insulin Resistance in Obese and/or Diabetic Animals by 5-[4-(1-Methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione (ADD-3878, U-63,287, Ciglitazone), a New Antidiabetic Agent

Takeshi Fujita, Yasuo Sugiyama, Shigehisa Taketomi et al. · Diabetes · 1983 · 270 citations

Diabetic Animals, Metabolic Disorder, New Antidiabetic Agent +20