Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21CIP-dependent pathways

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Goberdhan P. Dimri, X Lee, George Basile et al. · Proceedings of the National Academy of Sciences · 1995 · 7.3K citations · Full text

Replicative Senescence, Developmental Biology, Aging +14

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

Martin Scheffner, Bruce A. Werness, Jon M. Huibregtse et al. · Cell · 1990 · 4K citations

Human Papillomavirus Vaccines, Medicine, Pathology +10

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

Nicholas J. Dyson, Peter M. Howley, Karl Münger et al. · Science · 1989 · 3K citations

Rb1 Gene Product, Tumor Biology, Retinoblastoma Gene +13

Structure and transcription of human papillomavirus sequences in cervical carcinoma cells

Elisabeth Schwarz, U.K. Freese, Lutz Gissmann et al. · Nature · 1985 · 1.5K citations

Human Papillomavirus Sequences, Cervical Carcinoma Cells, Viral Replication +12

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

Peter Whyte, Karen Buchkovich, Jonathan M. Horowitz et al. · Nature · 1988 · 1.4K citations

Adenovirus E1a, Oncogenic Agent, Pathology +9