Specific Racemization and Isomerization of the Aspartyl Residue of αA-Crystallin Due to UV-B Irradiation

Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation.

Terrence L. Geiger, Steven Clarke · Journal of Biological Chemistry · 1987 · 1.3K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

Alex E. Roher, Jonathan D. Lowenson, Steven Clarke et al. · Journal of Biological Chemistry · 1993 · 799 citations · Full text

Life Sciences, Neurology, Neuroscience +17

Succinimide Formation from Aspartyl and Asparaginyl Peptides as a Model for the Spontaneous Degradation of Proteins

Robert C. Stephenson, Steven Clarke · Journal of Biological Chemistry · 1989 · 518 citations · Full text

Life Sciences, Biochemistry, Post-translational Modification +14

Determination of free amino acid enantiomers in rat brain and serum by high-performance liquid chromatography after derivatization with N-tert.-butyloxycarbonyl-l-cysteine and o-phthaldialdehyde

Atsushi Hashimoto, T Nishikawa, Takae Oka et al. · Journal of Chromatography B Biomedical Sciences and Applications · 1992 · 302 citations

Life Sciences, Biochemistry, Neuroscience +5

Simultaneous racemization and isomerization at specific aspartic acid residues in αB-crystallin from the aged human lens

N. FUJII, Yoshihiro Ishibashi, Kenshi Satoh et al. · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · 1994 · 206 citations

Life Sciences, Biochemistry, Molecular Biology +9