Sensitive CE–MS analysis of potentially genotoxic alkylation compounds using derivatization and electrokinetic injection

A rationale for determining, testing, and controlling specific impurities in pharmaceuticals that possess potential for genotoxicity

Lutz Müller, Robert J. Mauthe, Christopher M. Riley et al. · Regulatory Toxicology and Pharmacology · 2006 · 461 citations

Pharmacy, Pharmaceutics, Toxicology +12

Liquid Sheath Effects on the Separation of Proteins in Capillary Electrophoresis/Electrospray Mass Spectrometry

František Foret, Toni J. Thompson, Paul Vouros et al. · Analytical Chemistry · 1994 · 158 citations

Natural Sciences, Biochemistry, Chemistry +11

The application of structure-based assessment to support safety and chemistry diligence to manage genotoxic impurities in active pharmaceutical ingredients during drug development

Krista L. Dobo, Nigel Greene, Michelle O. Cyr et al. · Regulatory Toxicology and Pharmacology · 2006 · 127 citations

Pharmacy, Pharmaceutics, Toxicology +16

A practical derivatization LC/MS approach for determination of trace level alkyl sulfonates and dialkyl sulfates genotoxic impurities in drug substances

Jianguo An, Mingjiang Sun, Lin Bai et al. · Journal of Pharmaceutical and Biomedical Analysis · 2008 · 78 citations

Pharmacy, Pharmaceutical Analysis, Toxicology +17

On‐line capillary electrophoresis‐mass spectrometry using dopant‐assisted atmospheric pressure photoionization: Setup and system performance

Roelof Mol, Gerhardus J. de Jong, Govert W. Somsen · Electrophoresis · 2004 · 71 citations

Natural Sciences, Chemistry, Analytical Chemistry +14