Oxidative Metabolism of Amprenavir in the Human Liver. Effect of the CYP3A Maturation

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

Tsutomu Shimada, Hiroshi Yamazaki, Mayumi Mimura et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 2.8K citations

Medicine, Biochemistry, Pharmacology +15

Expression of CYP3A in the Human Liver — Evidence that the Shift between CYP3A7 and CYP3A4 Occurs Immediately After Birth

Dan Lacroix, Michelle Sonnier, A. Moncion et al. · European Journal of Biochemistry · 1997 · 540 citations

Life Sciences, Biochemistry, Developmental Biology +15

Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3).

Steven Wrighton, W. Brian, M.-A. Sari et al. · Molecular Pharmacology · 1990 · 403 citations

Medicine, Biochemistry, Pharmacology +12

Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes.

Gondi Kumar, A. David Rodrigues, Alex Buko et al. · Journal of Pharmacology and Experimental Therapeutics · 1996 · 352 citations

Medicine, Pharmacokinetics, Pharmacology +17

Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9

Sandra Baldwin, J. C. Bloomer, Graeme Smith et al. · Xenobiotica · 1995 · 298 citations

Medicine, Biochemistry, Pharmacology +17