Epigenetic mechanisms for silencing glutathione <i>S</i>‐transferase m2 expression by hypermethylated specificity protein 1 binding in lung cancer

Abstract

Epigenetic silencing of GST-M2 was distinguished from Sp1-mediated GST-M2 transcriptional expression. The authors concluded that this represents a mechanism that leads to decreased expression of GST-M2 in lung cancer cells.