Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

Mario F. Fraga, Esteban Ballestar, Ana Villar‐Garea et al. · Nature Genetics · 2005 · 1.9K citations

Life Sciences, Cancer Biology, Molecular Biology +13

Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells

Kip A. West, John Brognard, Amy S. Clark et al. · Journal of Clinical Investigation · 2003 · 512 citations · Full text

Life Sciences, Cell Biology, Toxicology +16

Global Levels of Histone Modifications Predict Prognosis in Different Cancers

David B. Seligson, Steve Horvath, Matthew A. McBrian et al. · American Journal Of Pathology · 2009 · 502 citations · Full text

Life Sciences, Molecular Biology, Oncology +16

Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells

Kip A. West, John Brognard, Amy S. Clark et al. · Journal of Clinical Investigation · 2003 · 501 citations · Full text

Life Sciences, Cell Biology, Toxicology +16

Evidence for an instructive mechanism of de novo methylation in cancer cells

Ilana Keshet, Yeshayahu Schlesinger, S. Farkash et al. · Nature Genetics · 2006 · 496 citations

Medicine, Cancer Biology, Molecular Biology +14