A Nuclear Complex of Rictor and Insulin Receptor Substrate-2 Is Associated with Albuminuria in Diabetic Mice

Abstract

We define a subset of signaling markers closely associated with albuminuria. Mammalian target of rapamycin complex 2 (mTORC2)::IRS complexes may play a role in the nuclear accumulation, and possible downstream transcriptional effects, of p-PKC. The activity and apparent safety of nephrilin in rodents suggest a novel intervention strategy for diabetic kidney disease.