Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-κB in HL-60 cells

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

Naoufal Zamzami, Philippe Marchetti, Maria Castedo et al. · The Journal of Experimental Medicine · 1995 · 1.2K citations · Full text

Life Sciences, Cell Biology, Immunology +14

The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial

David Grimwade · Blood · 2001 · 918 citations · Full text

Life Sciences, Hematology, Oncology +14

Nuclear factor-κB is constitutively activated in primitive human acute myelogenous leukemia cells

Mónica L. Guzmán, Sarah J. Neering, Donna Upchurch et al. · Blood · 2001 · 757 citations

Medicine, Cell Biology, Oncology +7

Targeting Nuclear Factor-κB Activation Pathway by Thymoquinone: Role in Suppression of Antiapoptotic Gene Products and Enhancement of Apoptosis

Gautam Sethi, Kwang Seok Ahn, Bharat B. Aggarwal · Molecular Cancer Research · 2008 · 316 citations

Life Sciences, Medicinal Chemistry, Pharmacology +15

Targeting NF- B activation via pharmacologic inhibition of IKK2-induced apoptosis of human acute myeloid leukemia cells

Catherine Frelin · Blood · 2004 · 144 citations · Full text

Life Sciences, Oncology, Pharmacology +17