Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma

Masashi Yanae, Masanobu Tsubaki, Takao Satou, +4

Journal of Experimental & Clinical Cancer Research

Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway

Yasuhiro Kidera, Masanobu Tsubaki, Yuzuru Yamazoe, +10

Journal of Experimental & Clinical Cancer Research

Blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathways by statins reduces the expression of bFGF, HGF, and TGF-β as angiogenic factors in mouse osteosarcoma

Masanobu Tsubaki, Yuzuru Yamazoe, Masashi Yanae, +6

Cytokine

Ras/pi3k/akt PathwaysStatins ReducesMouse OsteosarcomaAngiogenesisImmunology +6

Bisphosphonate- and statin-induced enhancement of OPG expression and inhibition of CD9, M-CSF, and RANKL expressions via inhibition of the Ras/MEK/ERK pathway and activation of p38MAPK in mouse bone marrow stromal cell line ST2

Masanobu Tsubaki, Takao Satou, Tatsuki Itoh, +6

Molecular and Cellular Endocrinology

InflammationCytokineSclerostinSignal TransductionBone Morphogenic Protein +9

Overexpression of MDR1 and survivin, and decreased Bim expression mediate multidrug-resistance in multiple myeloma cells

Masanobu Tsubaki, Takao Satou, Tatsuki Itoh, +7

Leukemia Research

Hematological MalignancyTumor BiologyOncologyMedicineMultiple Myeloma Cells +5

Reduction of metastasis, cell invasion, and adhesion in mouse osteosarcoma by YM529/ONO-5920-induced blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathway

Masanobu Tsubaki, Takao Satou, Tatsuki Itoh, +4

Toxicology and Applied Pharmacology

Ras/pi3k/akt PathwayMouse OsteosarcomaMedicineReceptor Tyrosine KinasePathology +5

Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-κB in HL-60 cells

Kaori Shoji, Masanobu Tsubaki, Yuzuru Yamazoe, +9

Archives of Pharmacal Research

InflammationMangiferin Induces ApoptosisMitophagyXiap ExpressionsMedicine +9

Nitrogen-containing bisphosphonate, YM529/ONO-5920 (a novel minodronic acid), inhibits RANKL expression in a cultured bone marrow stromal cell line ST2

Shozo Nishida, Masanobu Tsubaki, Mayumi Hoshino, +7

Biochemical and Biophysical Research Communications

Bone Marrow FailureMedicineStem Cell MobilizationMolecular BiologyRankl Expression +5

Macrophage inflammatory protein‐1α induces osteoclast formation by activation of the MEK/ERK/c‐Fos pathway and inhibition of the p38MAPK/IRF‐3/IFN‐β pathway

Masanobu Tsubaki, Chisato Kato, Ai Isono, +8

Journal of Cellular Biochemistry

Increased risk of SSEs in bone-only metastatic breast cancer patients treated with zoledronic acid

Masashi Yanae, Shinichiro Fujimoto, Kaori Tane, +11

Journal of bone oncology