The impaired immune regulation of autoimmune hepatitis is linked to a defective galectin-9/tim-3 pathway

Abstract

Reduced levels of Tim-3 on CD4(pos) CD25(neg) effector cells and of Gal9 in T-regs contribute to impaired immunoregulation in AIH by rendering effector cells less prone to T-reg control and T-regs less capable of suppressing.