N-Methylanilide and N-methylbenzamide derivatives as phosphodiesterase 10A (PDE10A) inhibitors

Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties

Travis T. Wager, Xinjun Hou, Patrick R. Verhoest et al. · ACS Chemical Neuroscience · 2010 · 1K citations

Pharmaceutical Science, Drug Target, Engineering +22

Inhibition of the striatum-enriched phosphodiesterase PDE10A: A novel approach to the treatment of psychosis

Judith A. Siuciak, Douglas S. Chapin, John F. Harms et al. · Neuropharmacology · 2006 · 274 citations

Neuropsychology, Psychiatry, Psychotic Disorder +13

Oligoanthranilamides. Non-Peptide Subunits That Show Formation of Specific Secondary Structure

Steven J. Geib, Andrew D. Hamilton · Journal of the American Chemical Society · 1996 · 274 citations

Supramolecular Assembly, Anthranilamide Nucleus, Protein Assembly +15

Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1 <i>H</i> -pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia†Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1).

Patrick R. Verhoest, Douglas S. Chapin, Michael L. Corman et al. · Journal of Medicinal Chemistry · 2009 · 201 citations · Full text

Aromatic architecture. Use of the N-methylamide structure as a molecular splint

Kentaro Yamaguchi, Go Matsumura, Hiroyuki Kagechika et al. · Journal of the American Chemical Society · 1991 · 153 citations

Aromatic Architecture, Engineering, Chemical Analysis +14