Discovery of the First Selective Inhibitor of Excitatory Amino Acid Transporter Subtype 1

Anders A. Jensen, Mette N. Erichsen, Christina Nielsen, +3

Journal of Medicinal Chemistry

Synthesis and SAR study of new phenylimidazole-pyrazolo[1,5-c]quinazolines as potent phosphodiesterase 10A inhibitors

Battistina Asproni, Gabriele Murineddu, Amedeo Pau, +5

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistryMedicinePotent Phosphodiesterase 10ANatural Sciences +6

Detailed Characterization of the In Vitro Pharmacological and Pharmacokinetic Properties of N-(2-Hydroxybenzyl)-2,5-Dimethoxy-4-Cyanophenylethylamine (25CN-NBOH), a Highly Selective and Brain-Penetrant 5-HT2A Receptor Agonist

Anders A. Jensen, John D. McCorvy, Sebastian Leth‐Petersen, +6

Journal of Pharmacology and Experimental Therapeutics

Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors

Jan Kehler, Andreas Ritzén, Morten Langgård, +6

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPhosphodiesterase 10AMedicineAntiparasitic AgentPharmacotherapy +3

Synthesis and SAR study of novel tricyclic pyrazoles as potent phosphodiesterase 10A inhibitors

Antonio Dore, Battistina Asproni, Alessia Scampuddu, +4

European Journal of Medicinal Chemistry

Medicinal ChemistryMedicinePotent Phosphodiesterase 10ANatural SciencesRational Drug Design +9

The potential therapeutic use of phosphodiesterase 10 inhibitors

Jan Kehler, Andreas Ritzén, Daniel R. Greve

Expert Opinion on Therapeutic Patents

Medicinal ChemistryPhosphodiesterase 10MedicineNeuropharmacologyNeurochemical Biomarkers +10

Discovery and Development of ¹¹C-Lu AE92686 as a Radioligand for PET Imaging of Phosphodiesterase10A in the Brain

Jan Kehler, John Paul Kilburn, Sergio Estrada, +13

Journal of Nuclear Medicine

4-Aryl-5-(4-Piperidyl)-3-Isoxazolol GABA_A Antagonists:  Synthesis, Pharmacology, and Structure−Activity Relationships

Bente Frølund, Lars S. Jensen, Signe ı́ Stórustovu, +5

Journal of Medicinal Chemistry

New Synthesis and Tritium Labeling of a Selective Ligand for Studying High-Affinity γ-Hydroxybutyrate (GHB) Binding Sites

Stine B. Vogensen, Aleš Marek, Tina Bay, +6

Journal of Medicinal Chemistry

Novel selective PDE type 1 inhibitors cause vasodilatation and lower blood pressure in rats

M.L. Laursen, Lilliana Beck, Jan Kehler, +9

British Journal of Pharmacology