Concepedia

Structure-Activity Relations of Successful Pharmacologic Chaperones for Rescue of Naturally Occurring and Manufactured Mutants of the Gonadotropin-Releasing Hormone Receptor

Jo Ann Janovick, Mark T. Goulet, Eugene N. Bush, Jonathan Greer, David G. Wettlaufer, P. Michael Conn

Journal of Pharmacology and Experimental Therapeutics · 2003 · 137 citations · 17 references

DOI

References

17

Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants

Jean-Pierre Morello, Ali Salahpour, André Laperrière et al. · Journal of Clinical Investigation · 2000 · 556 citations · Full text

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Conformational disease

Ron R. Kopito, David Ron · Nature Cell Biology · 2000 · 314 citations

<i>Trans</i> -Suppression of Misfolding in an Amyloid Disease

Per Hammarström, Frank Schneider, Jeffery W. Kelly · Science · 2001 · 290 citations

Newly Synthesized Human δ Opioid Receptors Retained in the Endoplasmic Reticulum Are Retrotranslocated to the Cytosol, Deglycosylated, Ubiquitinated, and Degraded by the Proteasome

Ulla E. Petäjä‐Repo, Mireille Hogue, André Laperrière et al. · Journal of Biological Chemistry · 2001 · 209 citations · Full text

Rescue of Hypogonadotropic Hypogonadism-Causing and Manufactured GnRH Receptor Mutants by a Specific Protein-Folding Template: Misrouted Proteins as a Novel Disease Etiology and Therapeutic Target

Jo Ann Janovick, Guadalupe Maya‐Núñez, P. Michael Conn · The Journal of Clinical Endocrinology & Metabolism · 2002 · 187 citations