A fluorescence polarization-based interaction assay for hypoxia-inducible factor prolyl hydroxylases

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations · Full text

Genetics, Molecular Biology, Hif-1 Subunits +21

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

Panu Jaakkola, David R. Mole, Ya‐Min Tian et al. · Science · 2001 · 5.5K citations

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

Mircea Ivan, Keiichi Kondo, Haifeng Yang et al. · Science · 2001 · 4.7K citations · Full text

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

Andrew Epstein, Jonathan Gleadle, Luke A. McNeill et al. · Cell · 2001 · 3.3K citations · Full text

Redox Signaling, Molecular Physiology, Mammalian Homologs Define +11

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1  in normoxia

Edurne Berra · The EMBO Journal · 2003 · 1.3K citations · Full text

Hif Prolyl-hydroxylase 2, Key Oxygen Sensor, Biochemistry +9