Systematic Analysis of the Protein Interaction Network for the Human Transcription Machinery Reveals the Identity of the 7SK Capping Enzyme

A generic protein purification method for protein complex characterization and proteome exploration

Guillaume Rigaut, Anna Shevchenko, Berthold Rutz et al. · Nature Biotechnology · 1999 · 2.7K citations

Proteomic Technology, Biochemistry, Protein Folding +10

The Bromodomain Protein Brd4 Is a Positive Regulatory Component of P-TEFb and Stimulates RNA Polymerase II-Dependent Transcription

Moon Kyoo Jang, Kazuki Mochizuki, Meisheng Zhou et al. · Molecular Cell · 2005 · 1.3K citations · Full text

Transcriptional Regulation, Bromodomain Protein Brd4, Molecular Regulation +8

Recruitment of P-TEFb for Stimulation of Transcriptional Elongation by the Bromodomain Protein Brd4

Zhiyuan Yang, Jasper H. N. Yik, Ruichuan Chen et al. · Molecular Cell · 2005 · 1.1K citations · Full text

Transcriptional Regulation, Bromodomain Protein Brd4, Protein Expression +9

Involvement of the TIP60 Histone Acetylase Complex in DNA Repair and Apoptosis

Tsuyoshi Ikura, Vasily Ogryzko, Mikhaïl Grigoriev et al. · Cell · 2000 · 1K citations · Full text

Chromatin, Genome Instability, Chromatin Remodeling +7

Comprehensive proteomic analysis of the human spliceosome

Zhaolan Zhou, Lawrence J. Licklider, Steven P. Gygi et al. · Nature · 2002 · 886 citations

Bioinformatics, Proteomic Technology, Functional Genomics +6