Comprehensive proteomic analysis of the human spliceosome

Zhaolan Zhou, Lawrence J. Licklider, Steven P. Gygi, +1

Nature

BioinformaticsProteomic TechnologyFunctional GenomicsMedicineProteasome +4

Brain-Specific Phosphorylation of MeCP2 Regulates Activity-Dependent Bdnf Transcription, Dendritic Growth, and Spine Maturation

Zhaolan Zhou, Elizabeth J. Hong, Sonia Cohen, +11

Neuron

Synaptic PlasticityNeuroregenerationMolecular NeuroscienceDendritic GrowthBrain-specific Phosphorylation +8

The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans

Zhaolan Zhou, Mingjuan Luo, Katja Straesser, +3

Nature

Transcriptional RegulationNuclear ExportNatural SciencesGeneticsRna Splicing +11

Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly

Mingjuan Luo, Zhaolan Zhou, Keith Magni, +4

Nature

Transcriptional RegulationPre-mrna SplicingNatural SciencesGeneticsRna Splicing +8

Genome-Wide Activity-Dependent MeCP2 Phosphorylation Regulates Nervous System Development and Function

Sonia Cohen, Harrison W. Gabel, Martin Hemberg, +10

Neuron

Signal TransductionMolecular NeuroscienceDevelopmental BiologyMolecular RegulationMolecular Pathway +7

Locus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC

Deborah Y. Kwon, Ying-Tao Zhao, Janine M. Lamonica, +1

Nature Communications

Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses

Darren Goffin, Megan Allen, Le Zhang, +12

Nature Neuroscience

ChromatinGenome InstabilityDna BindingProtein StabilityGenetic Disorder +10

Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice

I-Ting Judy Wang, Megan Allen, Darren Goffin, +7

Proceedings of the National Academy of Sciences

Signal Transduction PathwaysAutism Spectrum DisordersEvent-related PotentialsSocial SciencesSignaling Pathway +15

Functional Association of U2 snRNP with the ATP-Independent Spliceosomal Complex E

Rita Das, Zhaolan Zhou, Robin Reed

Molecular Cell

ChromatinTranscriptional RegulationNatural SciencesGeneticsMolecular Biology +9

Dissecting Cell-Type Composition and Activity-Dependent Transcriptional State in Mammalian Brains by Massively Parallel Single-Nucleus RNA-Seq

Peng Hu, Emily Fabyanic, Deborah Y. Kwon, +3

Molecular Cell

ChromatinMammalian BrainsActivity-dependent Transcriptional StateSingle Cell SequencingMedicine +6