Concepedia

Identification and structure–activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway

Stefan Peukert, Rishi K. Jain, Adrian Geisser, Yingchuan Sun, Rui Zhang, Aaron Bourret, Adam Carlson, Jennifer DaSilva, Arun Ramamurthy, Joseph F. Kelleher

Bioorganic & Medicinal Chemistry Letters · 2008 · 35 citations · 6 references

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6

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1+/−p53−/− mice

Justyna T. Romer, Hiromichi Kimura, Susan Magdaleno et al. · Cancer Cell · 2004 · 521 citations · Full text

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In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice

Pilar Sánchez‐Gómez, Ariel Ruiz i Altaba · Mechanisms of Development · 2004 · 144 citations

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Potent Inhibitors of the Hedgehog Signaling Pathway

Shirley A. Brunton, J. H. A. STIBBARD, Lee L. Rubin et al. · Journal of Medicinal Chemistry · 2008 · 43 citations

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Structural Analogues of Smoothened Intracellular Loops as Potent Inhibitors of Hedgehog Pathway and Cancer Cell Growth

Jarrett R. Remsberg, Hong Lou, Sergey G. Tarasov et al. · Journal of Medicinal Chemistry · 2007 · 39 citations

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Diaminoindanes as Microsomal Triglyceride Transfer Protein Inhibitors

Gary M. Ksander, Reynalda deJesus, Andrew Yuan et al. · Journal of Medicinal Chemistry · 2001 · 32 citations · Full text

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