IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

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Nature

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Matthew G. Vander Heiden, Navdeep S. Chandel, Edward K. Williamson, +2

Cell

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Yasuyuki Suzuki, Yuzuru Imai, Hiroshi Nakayama, +3

Molecular Cell

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Identification of Omi/HtrA2 as a Mitochondrial Apoptotic Serine Protease That Disrupts Inhibitor of Apoptosis Protein-Caspase Interaction

R.P. Hegde, Srinivasa M. Srinivasula, Zhijia Zhang, +8

Journal of Biological Chemistry

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L. Miguel Martins, Ingram Iaccarino, Tencho Tenev, +8

Journal of Biological Chemistry

MitophagyApoptosisImmunologyCell DeathOxidative Stress +16

Caspase-9 Can Be Activated without Proteolytic Processing

Henning R. Stennicke, Quinn L. Deveraux, Eric W. Humke, +3

Journal of Biological Chemistry

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Blood

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Shou‐Jiang Gao, Chris Boshoff, Sukhanya Jayachandra, +3

Oncogene

Kshv Orf K9Signal TransductionMolecular VirologyGeneticsPathogenesis +8

The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity

Geert Loo, Marjan van Gurp, Ben Depuydt, +7

Cell Death and Differentiation

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Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis

Qi-Heng Yang, Robin Church-Hajduk, Jinyu Ren, +2

Genes & Development

MitophagyApoptosisCell DeathOmi/htra2 Catalytic CleavageIap Cleavage +14