Concepedia

Response Differences between Human CD4+ and CD8+ T-Cells during CD28 Costimulation: Implications for Immune Cell-Based Therapies and Studies Related to the Expansion of Double-Positive T-Cells during Aging

Isett Laux, Ali Khoshnan, Charles Tindell, D. Bae, Xiaoming Zhu, Carl H. June, Rita B. Effros, André E. Nel

Clinical Immunology · 2000 · 85 citations · 53 references

Concepts

Response DifferencesAutoimmune DiseaseT-regulatory CellImmunologyCd28 CostimulationAutoimmunityCd4 T Cell ResponsesHuman Cd4+Cellular Immune ResponseImmunotherapyMedicineCell BiologyImmunological Memory

References

53

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

Ella Bossy‐Wetzel · The EMBO Journal · 1998 · 1.2K citations · Full text

Signal Transduction, Mitochondrial Function, Biochemistry +11

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

Lawrence Boise, Andy J. Minn, Patricia J. Noel et al. · Immunity · 1995 · 1.2K citations · Full text

T Cell Survival, Cell Therapy, Adaptive Immune System +8

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

Mehrdad Matloubian, R J Concepcion, R Ahmed · Journal of Virology · 1994 · 1.1K citations · Full text

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

James D. Fraser, Bryan Irving, Gerald R. Crabtree et al. · Science · 1991 · 644 citations

Signal Transduction Pathways, Adaptive Immune System, T-regulatory Cell +17

Specific T Helper Cell Requirement for Optimal Induction of Cytotoxic T Lymphocytes against Major Histocompatibility Complex Class II Negative Tumors

Ferry Ossendorp, Erica Mengedé, Marcel Camps et al. · The Journal of Experimental Medicine · 1998 · 600 citations · Full text

Cytotoxic T Lymphocytes, Class Ii, T-regulatory Cell +17