Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension

The selectivity of protein kinase inhibitors: a further update

Jenny Bain, Lorna Plater, Matt Elliott et al. · Biochemical Journal · 2007 · 2.5K citations · Full text

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

Theonie Anastassiadis, Sean Deacon, Karthik Devarajan et al. · Nature Biotechnology · 2011 · 909 citations · Full text

Drug Target, Signal Transduction, Signaling Pathway +10

Survival in pulmonary arterial hypertension: a reappraisal of the NIH risk stratification equation

Thenappan Thenappan, Sanjiv J. Shah, Stuart Rich et al. · European Respiratory Journal · 2009 · 485 citations · Full text

Rho Kinase–Mediated Vasoconstriction Is Important in Severe Occlusive Pulmonary Arterial Hypertension in Rats

Masahiko Oka, Noriyuki Homma, Laimute Taraseviciene‐Stewart et al. · Circulation Research · 2007 · 331 citations

Acute Lung Injury, Hypertension, Pulmonary Hypertension +16

Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase

Karen A. Fagan, Masahiko Oka, Natalie R. Bauer et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 2004 · 301 citations

Acute Lung Injury, Hypertension, Lung Inflammation +19