Concepedia

Increased expression of the pro-apoptotic Bcl2 family member PUMA is required for mitochondrial release of cytochrome C and the apoptosis associated with skeletal myoblast differentiation

Atossa Shaltouki, Margot Freer, Yu Mei, Crystal M. Weyman

APOPTOSIS · 2007 · 41 citations · 46 references

Concepts

Mitochondrial ReleaseMitophagyMitochondrial FunctionGeneticsApoptosisCell DeathCytochrome CSkeletal Myoblast DifferentiationGene ExpressionMedicineCell BiologyOxidative Stress

References

46

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

Katsunori Nakano, Karen H. Vousden · Molecular Cell · 2001 · 2.3K citations · Full text

Novel Proapoptotic Gene, Apoptosis, Cell Death +5

PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells

Jian Yu, Lin Zhang, Paul M. Hwang et al. · Molecular Cell · 2001 · 1.3K citations · Full text

Apoptosis, Colorectal Cancer, Cell Death +5

A Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer Therapy

Pavel G. Komarov, Elena A. Komarova, Roman V. Kondratov et al. · Science · 1999 · 1.3K citations

Cancer Therapy, Chemoprevention Strategy, Apoptosis +17

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

John Jeffers, Evan Parganas, Youngsoo Lee et al. · Cancer Cell · 2003 · 868 citations · Full text

Tumor Biology, -Independent Apoptotic Pathways, Medicine +9

Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions

Jie Du, Xiaonan Wang, Christiane Miereles et al. · Journal of Clinical Investigation · 2004 · 698 citations

Muscle Function, Cytoskeleton, Cellular Physiology +21