Concepedia

Design, synthesis and biological evaluation of ezrin inhibitors targeting metastatic osteosarcoma

Mikell Paige, George W. Kosturko, Güllay Bulut, Matthew Miessau, Said Rahim, Jeffrey A. Toretsky, Milton L. Brown, Aykut Üren

Bioorganic & Medicinal Chemistry · 2013 · 25 citations · 26 references

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Concepts

References

26

ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons.

Shöichiro Tsukita, Kenichi Oishi, N Sato et al. · The Journal of Cell Biology · 1994 · 778 citations · Full text

, , +19

The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis

Chand Khanna, Xiaolin Wan, Seuli Bose et al. · Nature Medicine · 2004 · 713 citations

, , +3

Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators

Yanlin Yu, Javed Khan, Chand Khanna et al. · Nature Medicine · 2004 · 534 citations

, , +7

Osteogenic sarcoma with clinically detectable metastasis at initial presentation.

Paul A. Meyers, Glenn Heller, John H. Healey et al. · Journal of Clinical Oncology · 1993 · 392 citations

Association of Ezrin with Intercellular Adhesion Molecule-1 and -2 (ICAM-1 and ICAM-2)

Leena Heiska, Kaija Alfthan, Mikaela Grönholm et al. · Journal of Biological Chemistry · 1998 · 324 citations · Full text