Synthesis and structure–activity relationships of N2-alkylated quaternary β-carbolines as novel antitumor agents

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes.

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Cell Proliferation, Cytoskeleton, Cell Cycle +20

Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells

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Tumor Biology, Chromatin, Chromatin Structure +14

Novel IKK inhibitors: β-carbolines

Alfredo Castro, François Soucy, Louis Grenier et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 241 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Biochemistry +9

Polo-like Kinase-1 Is Required for Bipolar Spindle Formation but Is Dispensable for Anaphase Promoting Complex/Cdc20 Activation and Initiation of Cytokinesis

Marcel A.T.M. van Vugt, Barbara C. M. van de Weerdt, Gerben Vader et al. · Journal of Biological Chemistry · 2004 · 203 citations · Full text

Bipolar Spindle Formation, Bipolar Spindle, Signal Transduction +15

Specific inhibition of cyclin-dependent kinases and cell proliferation by harmine

Yongcheng Song, Djohan Kesuma, Jian Wang et al. · Biochemical and Biophysical Research Communications · 2004 · 179 citations

Specific Inhibition, Signal Transduction, Medicine +7