Concepedia

Accurate and fast estimation of taxonomic profiles from metagenomic shotgun sequences

Theodore Gibbons, Mohammad Ghodsi, Todd J. Treangen, Mihai Pop

BMC Genomics · 2011 · 203 citations · 13 references

DOIFull text

Open access

Abstract

We have introduced a novel taxonomic classification method for analyzing the microbial diversity from whole-metagenome shotgun sequences. Compared with previous approaches, MetaPhyler is much more accurate in estimating the phylogenetic composition. In addition, we have shown that MetaPhyler can be used to guide the discovery of novel organisms from metagenomic samples.

References

13

Basic local alignment search tool

Stephen F. Altschul, Warren Gish, Webb Miller et al. · Journal of Molecular Biology · 1990 · 92.8K citations

, , +10

Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy

Qiong Wang, George M Garrity, James M. Tiedje et al. · Applied and Environmental Microbiology · 2007 · 20K citations · Full text

A core gut microbiome in obese and lean twins

Peter J. Turnbaugh, Micah Hamady, Tanya Yatsunenko et al. · Nature · 2008 · 7.8K citations · Full text

, , +9

MEGAN analysis of metagenomic data

Daniel H. Huson, Alexander F. Auch, Ji Qi et al. · Genome Research · 2007 · 3.4K citations · Full text

Human gut microbiota in obesity and after gastric bypass

Husen Zhang, John K. DiBaise, Andrea Zuccolo et al. · Proceedings of the National Academy of Sciences · 2009 · 1.9K citations · Full text

, , +21