Journal of Microelectromechanical Systems · 2012 · 42 citations · 28 references
EngineeringBioengineeringBiomedical EngineeringBiomedical OpticsMicroelectromechanical SystemsOpticsOptical CoherenceOptical Coherence TomographyOptical DiagnosticsOptical ImagingOptical TomographyTissue OpticsHigh-resolution ImagingOptical Coherence Tomography InstrumentationOptical Coherence Tomography ProbesProbe Design
This paper reports a miniature optical coherence tomography (OCT) probe and high-resolution 3-D OCT imaging results obtained with this side-view probe. The probe is only 2.8 mm in diameter, enabled by a unique high-fill-factor electrothermal MEMS mirror with hidden actuators and a novel wire-bonding-free packaging technique. The MEMS mirror has a large mirror aperture of 1 mm with a chip size of only 1.55 mm <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex Notation="TeX">$\times$</tex></formula> 1.7 mm <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\times$</tex></formula> 0.5 mm. The fabricated device achieves large 2-D scan optical angles up to 46 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$^{\circ}$</tex> </formula> at only 4.8 V. The specific time-domain OCT system utilized is detailed, and the assembled side-view probe demonstrates multiple high-resolution 3-D OCT imaging results that demonstrate detailed images of a mouse ear and images detecting the presence of tumor cells, and the contrast with a normal tissue is qualitatively analyzed. <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\hfill$</tex></formula> [2011-0369]
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David Huang, Eric A. Swanson, Charles P. Lin et al. · Science · 1991 · 13.7K citations
In Vivo Endoscopic Optical Biopsy with Optical Coherence Tomography
Guillermo J. Tearney, Mark E. Brezinski, Brett E. Bouma et al. · Science · 1997 · 1.4K citations
Imaging of Macular Diseases with Optical Coherence Tomography
Carmen A. Puliafito, Michael R. Hee, Charles P. Lin et al. · Ophthalmology · 1995 · 1.3K citations
Diagnosis of specialized intestinal metaplasia by optical coherence tomography
John M. Poneros, Stephan Brand, Brett E. Bouma et al. · Gastroenterology · 2001 · 278 citations · Full text
Engineering, Pathobiology, Pathology +12