Apoptotic activity of betulinic acid derivatives on murine melanoma B16 cell line

Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis

Emily Pisha, Heebyung Chai, Ik‐Soo Lee et al. · Nature Medicine · 1995 · 886 citations

Life Sciences, Medicinal Chemistry, Pharmacology +14

Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid

Simone Fulda, Carsten Scaffidi, Santos A. Susín et al. · Journal of Biological Chemistry · 1998 · 374 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Betulinic acid induces apoptosis in human neuroblastoma cell lines

Mary Lou Schmidt, K.L Kuzmanoff, L. Ling-Indeck et al. · European Journal of Cancer · 1997 · 173 citations

Life Sciences, Cell Biology, Oncology +11

Synthesis of betulinic acid derivatives with activity against human melanoma

Darrick S. H. L. Kim, John M. Pezzuto, Emily Pisha · Bioorganic & Medicinal Chemistry Letters · 1998 · 156 citations

Pharmacy, Medicinal Chemistry, Oncology +8

Betulinic Acid-Induced Apoptosis in Glioma Cells: A Sequential Requirement for New Protein Synthesis, Formation of Reactive Oxygen Species, and Caspase Processing

Wolfgang Wick, Cornelia Grimmel, Bettina Wagenknecht et al. · Journal of Pharmacology and Experimental Therapeutics · 1999 · 143 citations

Life Sciences, Cell Biology, Oncology +17