The Ubiquitin Peptidase UCHL1 Induces G0/G1 Cell Cycle Arrest and Apoptosis Through Stabilizing p53 and Is Frequently Silenced in Breast Cancer

Abstract

UCHL1 exerts its tumor suppressive functions by inducing G0/G1cell cycle arrest and apoptosis in breast tumorigenesis, requiring its deubiquitinase activity. Its frequent silencing by promoter CpG methylation may serve as a potential tumor marker for breast cancer.

References

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	Year	Citations
The UCH-L1 Gene Encodes Two Opposing Enzymatic Activities that Affect α-Synuclein Degradation and Parkinson's Disease Susceptibility Yichin Liu, Lara Fallon, Hilal A. Lashuel, Cell Disease SusceptibilityNeurodegenerative DiseasesMolecular NeuroscienceDisease MechanismSynaptic Signaling	2002	787
USP10 Regulates p53 Localization and Stability by Deubiquitinating p53 Jian Yuan, Kuntian Luo, Lizhi Zhang, Cell MedicineTumor SuppressorCancer BiologyCell BiologyTumor Biology	2010	629
Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion. Ute M. Moll, G Riou, Arnold J. Levine Proceedings of the National Academy of Sciences Distinct MechanismsBreast OncologyPathologyP53 ProteinCancer Biology	1992	580
Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron Hitoshi Osaka Human Molecular Genetics	2003	358
Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation Jianming Ying, H Li, T J Seng, Oncogene Functional EpigeneticsFrequent MethylationOncologyEsophageal CancerMedicine	2005	251
PGP9.5 Promoter Methylation Is an Independent Prognostic Factor for Esophageal Squamous Cell Carcinoma Diana Mandelker, Keishi Yamashita, Yutaka Tokumaru, Cancer Research	2005	217
The Tumor Suppressor UCHL1 Forms a Complex with p53/MDM2/ARF to Promote p53 Signaling and Is Frequently Silenced in Nasopharyngeal Carcinoma Lili Li, Qian Tao, Hongchuan Jin, Clinical Cancer Research	2010	170
A simple and fast densitometric method for the analysis of tyrosine hydroxylase immunoreactivity in the substantia nigra pars compacta and in the ventral tegmental area Léder Leal Xavier, Giordano Gübert Viola, Anete Curte Ferraz, Brain Research Protocols Fast Densitometric MethodBiochemistryTyrosine Hydroxylase ImmunoreactivityPharmacologyVentral Tegmental Area	2005	169
Defective de novo methylation of viral and cellular DNA sequences in ICF syndrome cells Qian Tao Human Molecular Genetics ChromatinIcf SyndromeGenetic DisorderEpigenetic ChangeGenetics	2002	156
Epigenetic identification of ubiquitin carboxyl‐terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors† Jun Yu, Qian Tao, Kin F. Cheung, Hepatology	2008	151

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