Concepedia

The Ubiquitin Peptidase UCHL1 Induces G0/G1 Cell Cycle Arrest and Apoptosis Through Stabilizing p53 and Is Frequently Silenced in Breast Cancer

Tingxiu Xiang, Lili Li, Xuedong Yin, Yuan Chenfu, Cui Tan, Xianwei Su, Lei Xiong, Thomas Choudary Putti, Michael D. Oberst, Kathleen Kelly,

PLoS ONE · 2012 · 133 citations · 31 references

DOIFull text

Open access

Abstract

UCHL1 exerts its tumor suppressive functions by inducing G0/G1cell cycle arrest and apoptosis in breast tumorigenesis, requiring its deubiquitinase activity. Its frequent silencing by promoter CpG methylation may serve as a potential tumor marker for breast cancer.

References

31

The UCH-L1 Gene Encodes Two Opposing Enzymatic Activities that Affect α-Synuclein Degradation and Parkinson's Disease Susceptibility

Yichin Liu, Lara Fallon, Hilal A. Lashuel et al. · Cell · 2002 · 787 citations · Full text

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USP10 Regulates p53 Localization and Stability by Deubiquitinating p53

Jian Yuan, Kuntian Luo, Lizhi Zhang et al. · Cell · 2010 · 629 citations · Full text

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Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion.

Ute M. Moll, G Riou, Arnold J. Levine · Proceedings of the National Academy of Sciences · 1992 · 580 citations · Full text

, , +16

Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron

Hitoshi Osaka · Human Molecular Genetics · 2003 · 358 citations

Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation

Jianming Ying, H Li, T J Seng et al. · Oncogene · 2005 · 251 citations

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