Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

Jun S. Liu, Jesse D. Farmer, Willam S. Lane et al. · Cell · 1991 · 4.1K citations

Protein Function, Signal Transduction, Biochemistry +9

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

Neil A. Clipstone, Robert H. Crabtree · Nature · 1992 · 1.6K citations

Signal Transduction, Laboratory Immunology, T-regulatory Cell +10

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

Hajime Karasuyama, Fritz Melchers · European Journal of Immunology · 1988 · 1.1K citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

W. Michael Flanagan, Blaise Corthésy, Richard J. Bram et al. · Nature · 1991 · 1.1K citations

Transcriptional Regulation, Signal Transduction, Cell Regulation +12

Molecular and biological characterization of a murine ligand for CD40

Richard J. Armitage, William C. Fanslow, L Strockbine et al. · Nature · 1992 · 1K citations

Molecular Immunology, Murine Ligand, Immunology +7