The cytoskeleton plays a modulatory role in the association between STIM1 and the Ca2+ channel subunits Orai1 and TRPC1

STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane

Shenyuan L. Zhang, Ying Yu, Jack Roos et al. · Nature · 2005 · 1.4K citations · Full text

Signal Transduction, Molecular Physiology, Ca2+ Sensor +7

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

Chan Young Park, Paul Hoover, Franklin M. Mullins et al. · Cell · 2009 · 938 citations · Full text

Activates Crac Channels, Signal Transduction, Molecular Physiology +11

Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine

Fernanda G. De Felice, Pauline T. Velasco, Mary P. Lambert et al. · Journal of Biological Chemistry · 2007 · 867 citations · Full text

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

Joseph P. Yuan, Weizhong Zeng, Michael R. Dorwart et al. · Nature Cell Biology · 2009 · 660 citations · Full text

Signal Transduction, Molecular Biology, Ion Channels +3

Structural and Mechanistic Insights into STIM1-Mediated Initiation of Store-Operated Calcium Entry

Peter B. Stathopulos, Le Zheng, Guangyao Li et al. · Cell · 2008 · 464 citations · Full text

Protein Secretion, Signal Transduction, Molecular Physiology +13