UCSF Chimera—A visualization system for exploratory research and analysis

Eric F. Pettersen, Thomas D. Goddard, Conrad C. Huang, +4

Journal of Computational Chemistry

Interactive VisualizationExtensible Visualization SystemUcsf ChimeraEngineeringData Science +13

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

Dos D. Sarbassov, David A. Guertin, Siraj M. Ali, +1

Science

Molecular BiologyTumor BiologySignaling PathwayAkt/pkb ActivationReceptor Tyrosine Kinase +14

Temsirolimus, Interferon Alfa, or Both for Advanced Renal-Cell Carcinoma

Gary R. Hudes, Michael A. Carducci, Piotr Tomczak, +15

New England Journal of Medicine

High Frequency of Mutations of the <i>PIK3CA</i> Gene in Human Cancers

Yardena Samuels, Zhenghe Wang, Alberto Bardelli, +12

Science

EngineeringMonths470last 12Data ScienceData MiningMedicine +13

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Estela Jacinto, Robbie Loewith, Anja Schmidt, +4

Nature Cell Biology

Signal TransductionNatural SciencesCell InteractionActin CytoskeletonMolecular Biology +8

Novel Procedure for Modeling Ligand/Receptor Induced Fit Effects

Woody Sherman, Tyler Day, Matthew P. Jacobson, +2

Journal of Medicinal Chemistry

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

Peggy P. Hsu, Seong A. Kang, Jonathan Rameseder, +9

Science

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

Morris E. Feldman, Beth Apsel, Aino Uotila, +4

PLoS Biology

Drug TargetMrna TranslationMolecular BiologyPharmacotherapyChemical Biology +22

mTOR kinase structure, mechanism and regulation

Haijuan Yang, Derek G. Rudge, Joseph D. Koos, +3

Nature

Signal TransductionMolecular PhysiologySignaling PathwayReceptor Tyrosine KinaseCellular Biochemistry +5

Structure of the FKBP12-Rapamycin Complex Interacting with Binding Domain of Human FRAP

Jung‐Won Choi, Jie Chen, Stuart L. Schreiber, +1

Science

Crystal StructureHuman FrapMolecular PhysiologySignal TransductionProtein Assembly +13