Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

Andrew M. Intlekofer, Naofumi Takemoto, E. John Wherry, +15

Nature Immunology

Signal TransductionLymphocyte DevelopmentT-regulatory CellImmunologyAutoimmunity +5

Control of Effector CD8 ⁺ T Cell Function by the Transcription Factor <i>Eomesodermin</i>

Erika L. Pearce, Alan C. Mullen, Gislâine A. Martins, +14

Science

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

Marianne J.B. van Stipdonk, Edward E. Lemmens, Stephen P. Schoenberger

Nature Immunology

Naïve CtlsSingle Brief PeriodSignal TransductionImmunologyPathology +8

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

Jonathan W. Heusel, Robin L. Wesselschmidt, Sujan Shresta, +2

Cell

Hematological MalignancyRapid InductionCell DivisionGranulocyteMalignant Blood Disorder +8

The mTOR Kinase Determines Effector versus Memory CD8+ T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin

Rajesh R. Rao, Qingsheng Li, Kunle Odunsi, +1

Immunity

Signal TransductionAdaptive Immune SystemReceptor Tyrosine KinaseT-regulatory CellImmunology +8

Cutting Edge: Type I IFNs Provide a Third Signal to CD8 T Cells to Stimulate Clonal Expansion and Differentiation

Julie Curtsinger, Javier O. Valenzuela, Pujya Agarwal, +2

The Journal of Immunology

A bioactive designer cytokine for human hematopoietic progenitor cell expansion

Martina Fischer, Jutta Goldschmitt, Christian Peschel, +5

Nature Biotechnology

InflammationCytokineCell TherapyLymphocyte DevelopmentMedicine +10

Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

Fernando Cruz‐Guilloty, Matthew E. Pipkin, Ivana M. Djuretic, +5

The Journal of Experimental Medicine

Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins

Andrzej Maćkiewicz, Heidi Schooltink, Peter C. Heinrich, +1

The Journal of Immunology

A Spatially-Organized Multicellular Innate Immune Response in Lymph Nodes Limits Systemic Pathogen Spread

Wolfgang Kastenmüller, Parizad Torabi‐Parizi, Naeha Subramanian, +2

Cell

InflammationHost ResponseAutoimmune DiseasePathogenesisImmunology +9