IL-6 trans-Signaling-Dependent Rapid Development of Cytotoxic CD8+ T Cell Function

Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

Andrew M. Intlekofer, Naofumi Takemoto, E. John Wherry et al. · Nature Immunology · 2005 · 1.2K citations

Signal Transduction, Lymphocyte Development, T-regulatory Cell +7

Control of Effector CD8 ⁺ T Cell Function by the Transcription Factor <i>Eomesodermin</i>

Erika L. Pearce, Alan C. Mullen, Gislâine A. Martins et al. · Science · 2003 · 987 citations

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

Marianne J.B. van Stipdonk, Edward E. Lemmens, Stephen P. Schoenberger · Nature Immunology · 2001 · 843 citations

Naïve Ctls, Single Brief Period, Signal Transduction +10

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

Jonathan W. Heusel, Robin L. Wesselschmidt, Sujan Shresta et al. · Cell · 1994 · 828 citations

Hematological Malignancy, Rapid Induction, Cell Division +10

The mTOR Kinase Determines Effector versus Memory CD8+ T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin

Rajesh R. Rao, Qingsheng Li, Kunle Odunsi et al. · Immunity · 2010 · 630 citations · Full text

Signal Transduction, Adaptive Immune System, Receptor Tyrosine Kinase +10