Concepedia

Receptor for activated C kinase 1 promotes hepatocellular carcinoma growth by enhancing mitogen-activated protein kinase kinase 7 activity

Yuanyuan Guo, Wendie Wang, Jing Wang, Jiannan Feng, Qingyang Wang, Jianfeng Jin, Ming Lv, Xinying Li, Yan Li, Yuanfang Ma,

Hepatology · 2012 · 67 citations · 24 references

DOI

Abstract

Overexpressed RACK1 augments JNK activity and thereby promotes HCC growth through directly binding to MKK7 and enhancing MKK7 activity.

References

24

Hepatocellular carcinoma

Josep M. Llovet, Andrew K. Burroughs, Jordi Bruix · The Lancet · 2003 · 3.6K citations

Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways

Kyoko Arimoto, Hiroyuki Fukuda, Shinobu Imajoh‐Ohmi et al. · Nature Cell Biology · 2008 · 607 citations

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RACK1, A multifaceted scaffolding protein: Structure and function

David R. Adams, Dorit Ron, Patrick A. Kiely · Cell Communication and Signaling · 2011 · 461 citations · Full text

Loss of hepatic NF-κB activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation

Toshiharu Sakurai, Shin Maeda, Lufen Chang et al. · Proceedings of the National Academy of Sciences · 2006 · 403 citations · Full text

p38α suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathway

Lijian Hui, Latifa Bakiri, Andreas Mairhorfer et al. · Nature Genetics · 2007 · 354 citations

, , +12