Applied Spectroscopy Reviews · 2008 · 1.9K citations · 76 references
Natural SciencesBiochemistryChemistryBiomedical OpticsSpectroscopic AnalysisSpectroscopyAbsorption SpectroscopyInfrared SpectroscopyMolecular SpectroscopyOptical SpectroscopySpectral Data ProcessingSpectroscopy Of BiomoleculesFourier TransformFourier Transform Infrared SpectroscopyInfrared SpectraInfrared Spectroscopic AnalysisResonance FrequenciesSpectroscopic Tissue AnalysisSpectroscopic Tissue CharacterizationVibrational Frequencies
This review surveys recent advances in FTIR spectroscopy of natural tissues and cell biology, summarizing widely used peak frequencies and their assignments. The authors aim to compile a comprehensive database of molecular fingerprints to aid researchers in identifying key FTIR peaks and characterizing biological tissue chemistry. The review finds that peak assignments are largely consistent across methods, and that a unified frequency database can enhance research quality, particularly for cancer tissue analysis.
Abstract This article reviews some of the recent advances on FTIR spectroscopy in areas related to natural tissues and cell biology. It is the second review publication resulting from a detailed study on the applications of spectroscopic methods in biological studies and summarizes some of the most widely used peak frequencies and their assignments. The aim of these studies is to prepare a database of molecular fingerprints, which will help researchers in defining the chemical structure of the biological tissues introducing most of the important peaks present in the natural tissues. In spite of applying different methods, there seems to be a considerable similarity in defining the peaks of identical areas of the FTIR spectra. As a result, it is believed that preparing a unique collection of the frequencies encountered in FTIR spectroscopic studies can lead to significant improvements both in the quantity and quality of research and their outcomes. This article is the first review of its kind that provides a precise database on the most important FTIR characteristic peak frequencies for researchers aiming to analyze natural tissues by FTIR spectroscopy and will be of considerable assistance to those who are focusing on the analysis of cancerous tissues by FTIR spectroscopy.
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