Concepedia

A Novel Monoclonal Anti-CD81 Antibody Produced by Genetic Immunization Efficiently Inhibits Hepatitis C Virus Cell-Cell Transmission

Isabel Fofana, Fei Xiao, Christine Thumann, Marine Turek, Laetitia Zona, Rajiv G. Tawar, Fritz Grunert, John S. Thompson, Mirjam B. Zeisel, Thomas F. Baumert

PLoS ONE · 2013 · 62 citations · 46 references

DOIFull text

Open access

Abstract

A novel anti-CD81 mAb generated by genetic immunization efficiently blocks HCV spread and dissemination. This antibody will be useful to further unravel the role of virus-host interactions during HCV entry and cell-cell transmission. Furthermore, this antibody may be of interest for the development of antivirals for prevention and treatment of HCV infection.

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