Concepedia

Ablation of gly96/immediate early gene-X1 (gly96/iex-1) aggravates DSS-induced colitis in mice: Role for gly96/iex-1 in the regulation of NF-κB

Christian Sina, Alexander Arlt, Olga Gavrilova, Emilie Midtling, Marie L. Kruse, Susanne Sebens Müerköster, Rajiv Kumar, Ulrich R. Fölsch, Stefan Schreiber, Philip Rosenstiel,

Inflammatory Bowel Diseases · 2009 · 33 citations · 38 references

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Abstract

Based on the observation that genetic ablation of gly96/iex-1 triggers intestinal inflammation in mice, we demonstrate for the first time that gly96/iex-1 exerts strong antiinflammatory activity via its NF-kappaB-counterregulatory effect.

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