Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiation

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Andrew Fire, Siqun Xu, Mary K. Montgomery et al. · Nature · 1998 · 15.1K citations

Specific Genetic Interference, Natural Sciences, Genetics +9

Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative.

Elisabeth Buchdunger, J. Zimmermann, Helmut Mett et al. · PubMed · 1996 · 1.1K citations

Abl Protein-tyrosine Kinase, Cellular Pharmacology, Pharmacotherapy +21

Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571).

Bhushan Nagar, William G. Bornmann, Patricia Pellicena et al. · PubMed · 2002 · 940 citations

Crystal Structure, Mixed-phenotype Acute Leukemia, Molecular Biology +18

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

Jiangen Gong, Antonio Costanzo, Hongqiong Yang et al. · Nature · 1999 · 928 citations

Genome Instability, Cell Regulation, Cisplatin-induced Dna Damage +10

Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

Michael O. Hengartner, Ronald Ellis, Robert Horvitz · Nature · 1992 · 890 citations

Developmental Biology, Signal Transduction, Cell Signaling +7